An update to WSUS 3.0 SP2 on Windows Server 2008 R2 and Windows Server 2008 (both x64 and x86) seems to break Windows Server Update Services (WSUS) and/or Internet Information Services (IIS) making clients unable to update via WSUS showing error 0x80072EE2.
To me, the subversive update number is not clear yet. So, if you know for sure the exact update that does this, please comment.